Key result
Endovascular revascularization appears to have a positive effect on endothelial functioning in patients with peripheral arterial disease, though evidence is limited and some benefits may be transient.
Why the study?
The authors sought to explore the impact of lower limb revascularization on endothelial function in patients with peripheral arterial disease.
Does lower limb endovascular revascularization improve endothelial function in patients with peripheral arterial disease?
Systematic Review (n=466)
Does lower limb endovascular revascularization improve endothelial function in patients with peripheral arterial disease?
Answers are grounded in this paper and cite their sources.
This systematic review suggests that lower limb endovascular revascularization may improve endothelial function in patients with peripheral arterial disease, highlighting a potential mechanism for symptomatic benefit.
Peripheral arterial disease (PAD) is a major public health problem. Endothelial dysfunction represents an important mechanism in the development and progression of atherosclerosis, in part attributable to inflammation, platelet and smooth muscle activation, and arterial stiffening. The aim of this study was to explore the impact of lower limb revascularization on endothelial function in patients with PAD. We performed a comprehensive search of the academic literature using the PubMed and Embase databases to screen suitable records. Following the application of our search strategies, a total of eight studies were included in this review. Despite the limited available evidence, the dearth of academic literature suggests that revascularization has a positive effect on endothelial functioning. The effects of endovascular revascularization on endothelial functioning in patients with PAD are subject to further research.
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Kaczmarczyk et al. (2023) conducted a systematic review in Peripheral arterial disease (PAD) (n=466). Endovascular treatment (percutaneous transluminal angioplasty) vs. Baseline (before procedure) or conservative treatment was evaluated on Endothelial function (measured via FMD, RHI, IMT, and arterial stiffness). Endovascular revascularization appears to have a positive effect on endothelial functioning in patients with peripheral arterial disease, though evidence is limited and some benefits may be transient.
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