What question did this study set out to answer?

This research investigates the effects of treatment on long-term survival when survival curves cross, violating proportional hazards assumption.

January 1, 2005Statistics in Medicine

Long-term survival with non-proportional hazards: results from the Dutch Gastric Cancer Trial

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Authors

HPHein PutterBrighton and Sussex Medical School MSMitsuru SasakoYodogawa Christian Hospital HHH.H. HartgrinkLeiden University

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Implication

Randomized trial compares D1 and D2 lymph node dissection's impact on long-term survival, suggesting new analytical methods for non-proportional hazards.

Key Points

This research investigates the effects of treatment on long-term survival when survival curves cross, violating proportional hazards assumption.
Analyzed long-term follow-up data from the Dutch Gastric Cancer Trial
Compared two treatments: limited (D1) and extended (D2) lymph node dissection
Illustrated methods for evaluating survival data beyond standard Cox regression.
Survival curves showed crossing patterns, indicating non-proportional hazards.
Conventional Cox proportional hazards model was found inadequate for this analysis.
Alternative statistical methods were proposed for appropriate assessment of treatment effects.

Cite This Study

Putter et al. (2005) studied this question.

synapsesocial.com/papers/6a6ee845660549caf2c38e2c https://doi.org/10.1002/sim.2143

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Implication

Randomized trial compares D1 and D2 lymph node dissection's impact on long-term survival, suggesting new analytical methods for non-proportional hazards.

Long-term survival with non-proportional hazards: results from the Dutch Gastric Cancer Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Long-term survival with non-proportional hazards: results from the Dutch Gastric Cancer Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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