Key result
A low-sodium diet combined with enalapril switched on renin gene expression in the atrium of female Wistar rats, whereas ventricular tissue did not express the renin gene in either state.
Why the study?
Does a low-sodium diet combined with enalapril stimulate renin gene expression in the heart of female Wistar rats?
Does a low-sodium diet combined with enalapril stimulate renin gene expression in the heart of female Wistar rats?
This preclinical study demonstrates that renin gene expression can be induced in the rat atrium, but not the ventricle, by sodium depletion and ACE inhibition.
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Animal data on cardiac renin expression remain hypothesis-generating; human studies needed before clinical relevance.
Lou et al. (1993) studied Renin gene expression in the heart. Low-sodium diet + enalapril vs. Normal-sodium diet was evaluated on Renin mRNA expression in atrium and ventricle. A low-sodium diet combined with enalapril switched on renin gene expression in the atrium of female Wistar rats, whereas ventricular tissue did not express the renin gene in either state.
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