Key result
Expression levels of renin mRNA in the central nervous system of 4-week-old spontaneously hypertensive rats were approximately twofold higher than in age-matched Wistar-Kyoto rats.
Why the study?
Does administration of captopril or clonidine modulate renin gene expression in the brain of spontaneously hypertensive rats?
Population
4-week-old spontaneously hypertensive rats and age-matched Wistar-Kyoto control rats
Comparison
Administration of salt, captopril, or clonidine vs Untreated state / Wistar-Kyoto control strain
Design
Preclinical
Authors
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Rat models implicate extrarenal renin in hypertension pathogenesis; leaves open human relevance and therapeutic targeting.
Does administration of captopril or clonidine modulate renin gene expression in the brain of spontaneously hypertensive rats?
The brain renin-angiotensin system may play an important role in the pathogenesis of hypertension, as evidenced by elevated renin mRNA expression in spontaneously hypertensive rats that is modulated by captopril and clonidine.
Iwai et al. (1992) studied Hypertension. Salt, captopril, and clonidine vs. Wistar-Kyoto rats / untreated was evaluated on Expression levels of renin mRNA in various tissues. Expression levels of renin mRNA in the central nervous system of 4-week-old spontaneously hypertensive rats were approximately twofold higher than in age-matched Wistar-Kyoto rats.
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