Expression of the renin gene in extra-renal tissues of the rat
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Population
12-week-old female Wistar-Kyoto (WKY) rats
Comparison
Low-salt diet or high-salt diet for 2 weeks vs Normal-salt diet for 2 weeks
Design
Preclinical
Follow-up
2 weeks
Authors
Discussion
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Implication
Supports local renin-angiotensin systems in extra-renal tissues; hypothesis-generating and requires human validation before clinical consideration.
Structured PICO
P
Population
12-week-old female Wistar-Kyoto (WKY) rats
I
Intervention
Low-salt diet (0.007 mmol of NaCl/g) or high-salt diet (0.112 mmol of NaCl/g + 1.5% NaCl to drink) for 2 weeks
C
Comparator
Normal-salt diet (0.112 mmol of NaCl/g) for 2 weeks
O
Outcome
Renin mRNA levels in kidney, liver, and brain measured by RNAase-protection techniquesurrogate
The demonstration of renin gene expression in extra-renal tissues that is regulated independently of renal renin supports the existence of ubiquitous local renin-angiotensin systems.
Limitations
- Low levels of renin mRNA in lung and spleen are on occasion beyond the limits of sensitivity of the method
Cite This Study
Samani et al. (1988) studied this question.
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