January 1, 1986Journal of Cardiovascular Pharmacology
Regulation of Tissue Renin and Angiotensin Gene Expressions
Population
Rats and genetic strains used to study tissue renin and angiotensinogen gene expressions
Design
Preclinical
Authors
Discussion
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Implication
Caution against assuming uniform RAS effects across tissues; leaves open local angiotensin roles pending human validation.
Key Points
- To examine the tissue-specific regulation and genetic influences governing renin and angiotensinogen gene expression across various rat tissues.
- Measured renin and angiotensinogen mRNA levels and enzymatic activity across multiple rat tissues, including the kidney, heart, adrenal gland, liver, submandibular gland, and genital organs.
- Assessed changes in tissue gene expression following dietary sodium depletion, beta-adrenergic agonist administration, and across different genetic rat strains.
- Sodium depletion and beta-adrenergic stimulation upregulate renin gene expression in the kidney, heart, and adrenal gland, but not in the submandibular gland or genital organs.
- Submandibular gland and genital renin expressions respond selectively to androgens and developmental hormones, displaying strain-dependent variations in renin activity absent in renal tissue.
- Low-sodium intake elevates local angiotensinogen mRNA expression in target tissues without altering hepatic angiotensinogen mRNA levels.
Structured PICO
P
Population
Rats and genetic strains used to study tissue renin and angiotensinogen gene expressions
I
Intervention
Sodium depletion, beta-adrenergic agonists, and androgens
O
Outcome
Tissue-specific regulation of renin and angiotensinogen gene expressionssurrogate
Tissue-specific regulation of renin and angiotensinogen gene expressions suggests that local angiotensin production may influence tissue responses independently of the circulating system.
Cite This Study
Dzau et al. (1986) studied this question.