January 1, 1991Kidney & Blood Pressure Research
Evolving Concepts of the Intrarenal Renin-Angiotensin System in Health and Disease: Contributions of Molecular Biology
Population
Preclinical models including experimental heart failure and spontaneously hypertensive rats
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Confirms intrarenal RAS feedback regulation in animals; leaves open translation to human hypertension or heart failure management.
Structured PICO
P
Population
Preclinical models including experimental heart failure and spontaneously hypertensive rats
I
Intervention
Dietary NaCl restriction and Ang II administration
O
Outcome
Intrarenal expression of renin, angiotensinogen, and angiotensin-converting enzyme messenger RNAssurrogate
Molecular biology techniques confirm the existence of an endogenous intrarenal renin-angiotensin system that is regulated by feedback mechanisms and altered in pathophysiological states like heart failure and hypertension.
Cite This Study
Schunkert et al. (1991) studied this question.