Population
Male 12-16-wk-old Wistar Kyoto WKY rats (n=10 for the salt diet experiment)
Comparison
Salt-depleted diet (0.02% NaCl) for 14 days vs Salt-repleted diet (1.6% NaCl) for 14 days
Design
Preclinical, Investigators were blinded as to the sodium diets of the animals…
Follow-up
14 days
Authors
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Animal data support intrarenal angiotensinogen regulation by sodium; hypothesis-generating and requires confirmation in higher models before clinical consideration.
Angiotensinogen mRNA is predominantly localized in the proximal renal tubule and is upregulated by sodium depletion, supporting the existence of a local intrarenal renin-angiotensin system.
Ingelfinger et al. (1990) studied this question.
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