Key result
Rat pancreas expresses angiotensinogen and renin genes, supporting an intrinsic renin-angiotensin system.
Why the study?
Previous studies suggested the presence of an intrinsic renin-angiotensin system in the pancreas, but gene expression and localization of key components needed further investigation.
Population
Rat pancreas tissue samples
Design
Gene expression and protein localization study using RT-PCR, Western blotting, and immunohistochemistry
Authors
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Hypothesis-generating for local pancreatic RAS; leaves open relevance to human islet function or metabolic disease.
Leung et al. (1999) studied this question. The rat pancreas expresses major renin-angiotensin system component genes, notably angiotensinogen and renin, supporting the presence of an intrinsic RAS.
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