Key result
Pancreatic endocrine tumours demonstrated an increase in the mRNA expression of angiotensinogen and AT2 receptor when compared with normal pancreas.
Authors
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Findings remain preclinical; leaves open whether AT2 upregulation offers a therapeutic target in pancreatic endocrine tumors.
Observational
Lam et al. (2002) conducted an observational in Pancreatic endocrine tumours (PETs). Pancreatic endocrine tumours vs. Normal pancreas was evaluated on Gene expression of key RAS components (angiotensinogen and AT1/AT2 receptors). Pancreatic endocrine tumours demonstrated an increase in the mRNA expression of angiotensinogen and AT2 receptor when compared with normal pancreas.
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