What question did this study set out to answer?

The aim is to identify the presence of a local angiotensin system in the pancreas.

August 1, 1991Journal of Hypertension

Evidence for an intrinsic angiotensin system in the canine pancreas

Q: What is the clinical evidence from this study?

Study design: Other. Primary outcome: Presence of angiotensinogen mRNA, protein, angiotensin II and binding sites in the canine pancreas.

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Key result

Angiotensinogen mRNA, angiotensinogen protein, angiotensin II, and high-affinity binding sites for angiotensin II are present in the canine pancreas.

Authors

MCMark C. ChappellWake Forest University AMAmy MillstedCleveland Clinic DDDebra I. DizVascular Medicine

Discussion

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Implication

May link hypertension to glucose dysregulation via pancreatic RAS; leaves open human relevance and therapeutic potential.

Key Points

The aim is to identify the presence of a local angiotensin system in the pancreas.
Examined pancreatic tissue for angiotensin components
Analyzed angiotensinogen mRNA and protein levels
Investigated presence of angiotensin II and its binding sites
Detected angiotensinogen mRNA in canine pancreas
Identified angiotensinogen protein and angiotensin II
Found high-affinity binding sites for angiotensin II in pancreatic tissue

PICO

Primary Outcome

Presence of angiotensinogen mRNA, protein, angiotensin II and binding sites in the canine pancreas

Cite This Study

Chappell et al. (1991) studied this question. Angiotensinogen mRNA, angiotensinogen protein, angiotensin II, and high-affinity binding sites for angiotensin II are present in the canine pancreas.

synapsesocial.com/papers/6a6b625847a1bfb288f31d5d https://doi.org/10.1097/00004872-199108000-00008

Topics

Hypertension management

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Evidence for an intrinsic angiotensin system in the canine pancreas

Discussion

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Implication

Key Points

PICO

Cite This Study

Topics

Evidence for an intrinsic angiotensin system in the canine pancreas

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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