Key result
Chronic hypoxia increases angiotensinogen and AT receptor expression in the rat pancreas versus normoxia.
Population
Sprague-Dawley rats
Comparison
Isobaric hypoxia (10% oxygen) for 4-5 weeks vs Age and time matched normoxic control rats…
Design
Preclinical
Follow-up
4-5 weeks
Authors
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Hypothesis-generating for hypoxia-induced pancreatic RAS activation; should not yet inform clinical practice or human studies.
Chronic hypoxia up-regulates the expression of renin-angiotensin system components in the rat pancreas, suggesting a role in physiological and pathophysiological responses.
Yew et al. (1999) studied this question. Isobaric hypoxia vs. Normoxic control (room air) was evaluated on Expression of RAS components (angiotensinogen, AT1a, AT1b, AT2). Chronic hypoxia increased the expression of angiotensinogen protein, its mRNA, and AT1a, AT1b, and AT2 receptors in the rat pancreas compared to normoxic controls.
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