Key result
Exposure of adult Sprague-Dawley rats to isobaric hypoxia caused a time-dependent increase in plasma renin activity and parallel upregulation of local pancreatic RAS components.
Why the study?
Does exposure to isobaric hypoxia activate the circulating and pancreatic renin-angiotensin system in adult Sprague-Dawley rats?
Population
Adult Sprague-Dawley rats
Design
Preclinical
Authors
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Hypoxia activates pancreatic RAS in rats; hypothesis-generating for human hypoxic stress responses and should not yet change practice.
Does exposure to isobaric hypoxia activate the circulating and pancreatic renin-angiotensin system in adult Sprague-Dawley rats?
Chronic hypoxia activates both the circulating and local pancreatic renin-angiotensin systems in a rat model, suggesting a role in physiologic and pathophysiologic responses to hypoxic stress.
Ip et al. (2002) studied Chronic hypoxia. Isobaric hypoxia (10% O2) was evaluated on Plasma renin activity and mRNA expression of angiotensinogen and angiotensin II receptor types I and II in the pancreas. Exposure of adult Sprague-Dawley rats to isobaric hypoxia caused a time-dependent increase in plasma renin activity and parallel upregulation of local pancreatic RAS components.
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