Why the study?
Does returning to normoxic conditions reverse the upregulation of pancreatic RAS components induced by chronic hypoxia in rats?
Population
Rats subjected to chronic hypoxia (10% oxygen) for one month
Comparison
Return to normoxic conditions for a varying… vs Respective controls
Design
Preclinical
Follow-up
Up to 4 weeks
Authors
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Reversibility of hypoxia-induced pancreatic RAS upregulation in rats; hypothesis-generating and requires human confirmation before clinical relevance.
Does returning to normoxic conditions reverse the upregulation of pancreatic RAS components induced by chronic hypoxia in rats?
The upregulation of the local pancreatic renin-angiotensin system induced by chronic hypoxia is reversible upon return to normoxic conditions in a time-dependent manner.
Ip et al. (2003) studied this question.
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