Key result
Exposure to chronic hypoxia (10% O2) produced progressive, reversible reductions in lung ACE activity and ANG II levels, while increasing kidney ACE activity in rats.
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Hypoxia-induced tissue ACE shifts in rats warrant caution extrapolating systemic RAS measures; leaves open organ-specific effects in human hypoxic disease.
Oparil et al. (1988) studied Hypoxia adaptation. Hypoxia (10% O2) vs. Air controls (normoxic environment) was evaluated on Angiotensin-converting enzyme (ACE) activity and stores of angiotensin I and II in lung, kidney, brain, and testis. Exposure to chronic hypoxia (10% O2) produced progressive, reversible reductions in lung ACE activity and ANG II levels, while increasing kidney ACE activity in rats.
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