What is the clinical evidence from this study?

Population: Hypertension (n=100). Intervention: Chronic normobaric hypoxia vs. Continuous normoxia. Primary outcome: Mean arterial pressure (MAP) after 14 days of exposure (p=<0.05).

February 15, 2015Physiological ResearchOpen Access

Combined Suppression of the Intrarenal and Circulating Vasoconstrictor Renin-ACE-ANG II Axis and Augmentation of the Vasodilator ACE2-ANG 1-7-Mas Axis Attenuates the Systemic Hypertension in Ren-2 Transgenic Rats Exposed to Chronic Hypoxia

Q: What are the key findings of this study?

Exposure to 14 days of chronic hypoxia significantly decreased mean arterial pressure in hypertensive Ren-2 transgenic rats compared to continuous normoxia (105 vs 157 mm Hg).

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Key result

Exposure to 14 days of chronic hypoxia significantly decreased mean arterial pressure in hypertensive Ren-2 transgenic rats compared to continuous normoxia (105 vs 157 mm Hg).

Why the study?

Does chronic hypoxia reduce blood pressure in Ren-2 transgenic rats?

Structured PICO

Does chronic hypoxia reduce blood pressure in Ren-2 transgenic rats?

Population

100 Ren-2 transgenic and normotensive Hannover Sprague-Dawley rats exposed to 14 days of chronic hypoxia to evaluate blood pressure and renin-angiotensin system changes.

Intervention

Exposure to chronic normobaric hypoxia (10% O2) for 14 days

Comparator

Continuous normoxia

Outcome

Systolic blood pressure (SBP) and mean arterial pressure (MAP)surrogate

Main Result

Absolute Event Rate: 105% vs 157%

p-value: p=<0.05

Chronic hypoxia paradoxically lowers blood pressure in a renin-dependent model of hypertension by suppressing the vasoconstrictor ACE-ANG II axis and augmenting the vasodilator ACE2-ANG 1-7 axis.

Limitations

Further studies are needed to clarify if the hypotensive effects of chronic hypoxia are specific for TGR only or are a feature characteristic for all ANG II-dependent models of hypertension.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating in Ren-2 rats; should not change clinical practice or guide human hypertension management.

Cite This Study

Červenka et al. (2015) studied Hypertension (n=100). Chronic normobaric hypoxia vs. Continuous normoxia was evaluated on Mean arterial pressure (MAP) after 14 days of exposure (p=<0.05). Exposure to 14 days of chronic hypoxia significantly decreased mean arterial pressure in hypertensive Ren-2 transgenic rats compared to continuous normoxia (105 vs 157 mm Hg).

synapsesocial.com/papers/6a8b8de9f8241cb45bfb5c96 https://doi.org/10.33549/physiolres.932842

Topics

Hypertension management

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Combined Suppression of the Intrarenal and Circulating Vasoconstrictor Renin-ACE-ANG II Axis and Augmentation of the Vasodilator ACE2-ANG 1-7-Mas Axis Attenuates the Systemic Hypertension in Ren-2 Transgenic Rats Exposed to Chronic Hypoxia

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Topics

Combined Suppression of the Intrarenal and Circulating Vasoconstrictor Renin-ACE-ANG II Axis and Augmentation of the Vasodilator ACE2-ANG 1-7-Mas Axis Attenuates the Systemic Hypertension in Ren-2 Transgenic Rats Exposed to Chronic Hypoxia

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

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