Population
Animal model of hypoxic pulmonary hypertension (isolated perfused lungs)
Comparison
Chronic hypoxia exposure with and without… vs Baseline/normoxia
Design
Preclinical
Follow-up
Up to 3 weeks of hypoxia and 3 weeks of normoxia recovery
Authors
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AT1 blockade merits targeted investigation in hypoxic PH; extends rodent receptor data but leaves open human translation.
Chronic hypoxia-induced pulmonary hypertension is associated with early, transient increases in AT1 and AT2 receptors, with the vasotonic response to Ang II mediated mainly by the AT1 subtype.
Chassagne et al. (2000) studied this question.
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