Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung
Key result
AT1 antagonist GR138950C reduces pulmonary arterial pressure ~25% vs saline in hypoxic rats.
- P<0.05
Why the study?
Does AT1 antagonism reduce pulmonary hypertension and cardiac remodeling in a rat model of hypoxia-induced pulmonary hypertension?
Population
Rat model of hypoxia-induced pulmonary hypertension (exposed to 10% fractional inspired O2 for 7 days)
Comparison
AT1 antagonist GR138950C, 1 mg kg-1 day-1… vs Saline alone during 7 days of exposure to…
Design
Preclinical
Follow-up
7 days
Authors
Discussion
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Implication
Hypothesis-generating in rat hypoxia model; leaves open translation to human pulmonary hypertension.
Structured PICO
Does AT1 antagonism reduce pulmonary hypertension and cardiac remodeling in a rat model of hypoxia-induced pulmonary hypertension?
P
Population
Rats exposed to hypoxia (10% fractional inspired O2) for 7 days to model hypoxia-induced pulmonary hypertension.
I
Intervention
AT1 antagonist GR138950C, 1 mg kg-1 day-1 intravenously during 7 days of exposure to hypoxia
C
Comparator
Saline alone during 7 days of exposure to hypoxia; also compared to a dose of sodium nitroprusside (SNP)
O
Outcome
Pulmonary arterial pressure, right ventricular hypertrophy (right/left ventricle weight ratio), and pulmonary artery remodelling (abundance of thick-walled pulmonary vessels)surrogate
Main Result
Absolute Event Rate: 21.3% vs 28.3%
p-value: p=< 0.05
AT1 receptor antagonism attenuates the development of hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in a rat model.
Cite This Study
Zhao et al. (1996) studied hypoxia-induced pulmonary hypertension. GR138950C vs. saline was evaluated on pulmonary arterial pressure (mmHg) (p=< 0.05). Treatment with the AT1 antagonist GR138950C during 7 days of hypoxia reduced pulmonary arterial pressure compared to saline (21.3 vs 28.3 mmHg; P<0.05) in rats.