Key result
AT1 and AT2 receptors localize predominantly to pancreatic blood vessels and ductal epithelia in rodents.
Why the study?
The localization of angiotensin II receptor subtypes AT1 and AT2 in the rodent pancreas was not fully characterized.
Population
Mouse and rat pancreas
Comparison
Immunocytochemistry for AT1 vs AT2 receptor localization
Design
Immunocytochemical study using specific antipeptide antibodies and confocal microscopy
Authors
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Hypothesis-generating for AT1/AT2 roles in rodent pancreatic function; does not yet inform human physiology or practice.
AT1 and AT2 receptors are localized in the endothelia of blood vessels and epithelia of the pancreatic ductal system in rodents, suggesting a role in regulating pancreatic functions.
Leung et al. (1997) studied this question. Immunocytochemistry for AT1 and AT2 receptors was evaluated on Localization of AT1 and AT2 receptors in the pancreas. Immunoreactivity for AT1 and AT2 receptors was observed predominantly in the endothelia of blood vessels and epithelia of the pancreatic ductal system in mice and rats.
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