Key result
Myocardial infarction stimulated the expression of exon 1A-renin mRNA in the left ventricle about 4-fold compared with sham-operated animals, with no preprorenin mRNA detectable.
Population
Rat model of myocardial infarction
Comparison
Myocardial infarction vs Sham-operated animals
Design
Preclinical
Authors
Loading...
Supports intracellular adrenal prorenin; extends tissue RAS concepts beyond secretory pathways.
Effect estimate: about 4-fold increase
The heart exclusively expresses an alternative renin transcript (exon 1A-mRNA) that is upregulated 4-fold post-myocardial infarction, suggesting an intracellular rather than secretory role for local cardiac renin.
Clausmeyer et al. (2000) studied Myocardial infarction. Myocardial infarction vs. Sham-operated animals was evaluated on Expression of exon 1A-renin mRNA in the left ventricle (about 4-fold increase). Myocardial infarction stimulated the expression of exon 1A-renin mRNA in the left ventricle about 4-fold compared with sham-operated animals, with no preprorenin mRNA detectable.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: