Population
Secreted renin (sRen)-specific knockout mice
Design
Preclinical
Authors
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Secreted renin is essential in mice; leaves open isoform-specific targeting in human hypertension.
Preservation of intracellular renin expression in the brain is insufficient to compensate for the loss of secreted renin, which is essential for survival, renal function, and arterial pressure regulation.
Xu et al. (2009) studied this question.
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