Key result
A novel, evolutionarily conserved brain-specific renin transcript (renin b) was identified, which generates an intracellular protein and provides evidence for a novel pathway of intracellular angiotensin generation.
Population
Rat genomic sequence, mice, humans, and transiently transfected AtT-20 cells
Comparison
Characterization of a novel renin transcript vs Classical renin transcript (renin a)
Design
Preclinical
Authors
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Hypothesis-generating for renin regulation; leaves open translational relevance to human cardiovascular disease.
The discovery of a brain-specific, intracellular renin isoform suggests a novel pathway for intracellular angiotensin generation in the brain.
Lee‐Kirsch et al. (1999) studied this question. A novel, evolutionarily conserved brain-specific renin transcript (renin b) was identified, which generates an intracellular protein and provides evidence for a novel pathway of intracellular angiotensin generation.
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