Key result
Three transcriptional isoforms of human renin mRNA were identified from alternative transcription start sites in kidney, brain, and lung, which were faithfully emulated in a transgenic mouse model.
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Three renin isoforms identified in transgenic mice; leaves open their role in human hypertension regulation.
Sinn et al. (2000) studied this question. Transgenic expression of human renin gene was evaluated on Identification of transcriptional isoforms of human renin mRNA. Three transcriptional isoforms of human renin mRNA were identified from alternative transcription start sites in kidney, brain, and lung, which were faithfully emulated in a transgenic mouse model.
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