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February 4, 2004AJP Regulatory Integrative and Comparative Physiology

Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype

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Population

Mice with a two-renin gene strain (Ren2 and Ren1d)

Comparison

Ablation of renin-expressing cells during… vs Wild-type mice

Design

Preclinical

Authors

EPEllen S. PentzJohns Hopkins UniversityMMMaría Alejandra MoyanoNational University of TucumánBTBarbara A. ThornhillUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Renin cell ablation impairs murine kidney integrity; leaves open translational relevance to human hypertension or CKD.

Structured PICO

P
Population
Mice with a two-renin gene strain (Ren2 and Ren1d)
I
Intervention
Ablation of renin-expressing cells during development by placing diphtheria toxin A chain (DTA) under control of the Ren1d mouse renin promoter by homologous recombination
C
Comparator
Wild-type mice
O
Outcome
Kidney morphology and function (including renin concentration, blood pressure, blood urea nitrogen, and potassium levels)surrogate

Ablation of renin-expressing cells in mice demonstrates that these cells are necessary for the morphological integrity and normal function of the kidney.

Cite This Study

Pentz et al. (2004) studied this question.

synapsesocial.com/papers/6a7165e1e5469ee92be1f1dehttps://doi.org/10.1152/ajpregu.00426.2003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EVOLUTION AND VARIATION OF RENIN GENES IN MICE1984 · 64 citations
  2. 2Distribution of renin mRNA and its protein in the developing kidney1989 · 216 citations
  3. 3Reduced growth, abnormal kidney structure, and type 2 (AT 2 ) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT 1A and AT 1B receptors for angiotensin II1998 · 318 citations
  4. 4Differential extra-renal expression of the mouse renin genes1989 · 49 citations
  5. 5Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes.1994 · 146 citations