Population
10- to 12-month-old female mice homozygous for a disruption of the converting enzyme gene and age-matched…
Comparison
Disruption of the converting enzyme gene vs Age-matched wild-type mice
Design
Preclinical
Authors
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ACE essential for normal murine renal development; leaves open implications for ACE inhibitor safety in human pregnancy.
Angiotensin-converting enzyme is necessary to preserve normal kidney architecture and the normal pattern of renin expression in mice.
Hilgers et al. (1997) studied this question.
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