November 24, 2004Journal of the American Society of Nephrology

Ren1c Homozygous Null Mice Are Hypotensive and Polyuric, but Heterozygotes Are Indistinguishable from Wild-Type

View Full Paper

Ask AI

Bookmark

Population

C57BL/6-derived mice (Ren1c-/-, Ren1c+/-, and wild-type +/+)

Comparison

Ren1c gene disruption vs Wild-type mice (+/+)

Design

Preclinical

Authors

NTNobuyuki TakahashiUniversity of North Carolina at Chapel Hill MSMaria Luisa S. Sequeira-LόpezUniversity of Virginia Health System JCJohn E. CowhigUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Renin-null mice confirm its irreplaceable role in angiotensin maintenance; leaves open human translation and therapeutic targeting.

Structured PICO

Population

C57BL/6-derived mice (Ren1c-/-, Ren1c+/-, and wild-type +/+)

Intervention

Ren1c gene disruption (homozygous null and heterozygous)

Comparator

Wild-type mice (+/+)

Outcome

Blood pressure, urine volume, urine osmolality, and plasma renin/angiotensin levelssurrogate

Renin is the only enzyme capable of maintaining plasma angiotensins, and its expression is tightly regulated at the mRNA level, as demonstrated by the hypotensive and polyuric phenotype of Ren1c null mice.

Cite This Study

Takahashi et al. (2004) studied this question.

synapsesocial.com/papers/6a719c58f44fa9f079df6072 https://doi.org/10.1681/asn.2004060490

View Full Paper

Ask AI

Bookmark

Ren1c Homozygous Null Mice Are Hypotensive and Polyuric, but Heterozygotes Are Indistinguishable from Wild-Type

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ren1c Homozygous Null Mice Are Hypotensive and Polyuric, but Heterozygotes Are Indistinguishable from Wild-Type

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider