Population
52 female F2 rats derived from spontaneously hypertensive rats and Wistar-Kyoto rats
Comparison
High salt (8%) diet for 14 days (n=18) vs Normal salt diet (n=34)
Design
Preclinical
Follow-up
14 days
Authors
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Salt modulates renin genotype-adrenal mRNA links in rat models; leaves open genetic control of aldosterone in hypertension.
The higher renin mRNA concentration in SHR adrenal glands is governed by the SHR allele of the renin gene, which paradoxically confers a lower rate of aldosterone synthesis.
Iwai et al. (1996) studied this question.
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