Why the study?
Does renal sympathetic denervation affect renal renin and angiotensinogen gene expression in spontaneously hypertensive rats during development?
Population
4-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar rats
Comparison
Denervation of the left kidney vs Sham operation
Design
Preclinical
Follow-up
Evaluated at age 5, 7, or 9 weeks
Authors
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Suggests sympathetic contribution to early renin expression in SHR; leaves open relevance to human hypertension or denervation therapy.
Does renal sympathetic denervation affect renal renin and angiotensinogen gene expression in spontaneously hypertensive rats during development?
Renal sympathetic nerves elevate renal renin gene expression in the prehypertensive stage of spontaneously hypertensive rats, but this influence decreases as hypertension develops.
Nakamura et al. (1995) studied this question.
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