Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1995Hypertension

Renal Nerves, Renin, and Angiotensinogen Gene Expression in Spontaneously Hypertensive Rats

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does renal nerve stimulation affect renin and angiotensinogen gene expression differently in spontaneously hypertensive rats compared to Wistar rats?

Population

Wistar rats and spontaneously hypertensive rats (SHR)

Comparison

Renal nerve stimulation for 1 hour to reduce… vs Wistar rats vs. spontaneously hypertensive rats

Design

Preclinical

Follow-up

1 hour

Authors

ANAkio NakamuraJuntendo University HospitalEJEdward J. JohnsUniversity College Cork

Discussion

Loading...

Member takes

Implication

Blunted renin responses to renal nerve stimulation in SHR suggest altered sympathetic-renin axis in hypertension; leaves open translation to human disease.

Structured PICO

Does renal nerve stimulation affect renin and angiotensinogen gene expression differently in spontaneously hypertensive rats compared to Wistar rats?

P
Population
Wistar rats and spontaneously hypertensive rats (SHR)
I
Intervention
Renal nerve stimulation for 1 hour to reduce renal blood flow by 15% and 30%
C
Comparator
Wistar rats vs. spontaneously hypertensive rats (and basal vs. stimulated states)
O
Outcome
Plasma renin activity, renal renin mRNA, and angiotensinogen mRNA contentssurrogate

The ability of renal nerves to increase renin release and gene expression of renin and angiotensinogen is depressed in spontaneously hypertensive rats compared to normotensive rats.

Cite This Study

Nakamura et al. (1995) studied this question.

synapsesocial.com/papers/6a8810143fe66a1452bbfa71https://doi.org/10.1161/01.hyp.25.4.581

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Widespread Abnormality of Renin Gene Expression in the Spontaneously Hypertensive Rat: Modulation in Some Tissues with the Development of Hypertension1989 · 48 citations
  2. 2Effect of acute renal denervation and ANF on renal function in adult spontaneously hypertensive rats1991 · 6 citations
  3. 3Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life1992 · 34 citations
  4. 4Molecular biology and pathophysiology of the intrarenal renin-angiotensin system1989 · 37 citations
  5. 5Effect of renal nerve stimulation, renal blood flow and adrenergic blockade on plasma renin activity in the cat1972 · 116 citations