Key result
Spontaneously hypertensive rats showed significantly increased renal mRNA expression of several RAS-related genes, including a 1.71-fold increase in AT1Ra (P<0.0001), compared to normotensive rats.
Authors
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Findings in hypertensive rat models warrant no clinical change; leaves open human relevance of renal RAS upregulation.
Effect estimate: 1.71-fold increase
p-value: p=<0.0001
Williamson et al. (2017) studied Hypertension (n=12). Spontaneous hypertension (SHR strain) vs. Normotensive Wistar-Kyoto rats (WKYs) was evaluated on Renal mRNA expression of AT1Ra (1.71-fold increase, p=<0.0001). Spontaneously hypertensive rats showed significantly increased renal mRNA expression of several RAS-related genes, including a 1.71-fold increase in AT1Ra (P<0.0001), compared to normotensive rats.
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