February 7, 2012HypertensionOpen Access

Tissue-Specific Upregulation of Angiotensin-Converting Enzyme 1 in Spontaneously Hypertensive Rats Through Histone Code Modifications

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Population

Normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs)

Comparison

Valsartan treatment (in SHRs) vs Untreated SHRs and normotensive WKY rats

Design

Preclinical

Authors

HLHae‐Ahm LeeKyung Hee University HCHyunmin ChoGuardia Civil DLDong-Youb LeeKyungpook National University

Discussion

Member takes

Implication

Ace1 epigenetic changes in this SHR model are hypothesis-generating; human relevance and therapeutic impact remain unproven.

Structured PICO

Population

Normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs)

Intervention

Valsartan treatment (in SHRs)

Comparator

Untreated SHRs and normotensive WKY rats

Outcome

Ace1 mRNA and protein expressions and histone modifications (H3Ac, H3K4me3, H3K9me2) in local tissues (adrenal gland, aorta, heart, kidney, liver, and lung)surrogate

ACE1 is upregulated in local tissues of spontaneously hypertensive rats via histone code modifications, which can be modulated by valsartan treatment.

Cite This Study

Lee et al. (2012) studied this question.

synapsesocial.com/papers/6a780759d3a6aa87c6be1946 https://doi.org/10.1161/hypertensionaha.111.182428

Topics

Hypertension management

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Tissue-Specific Upregulation of Angiotensin-Converting Enzyme 1 in Spontaneously Hypertensive Rats Through Histone Code Modifications

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Tissue-Specific Upregulation of Angiotensin-Converting Enzyme 1 in Spontaneously Hypertensive Rats Through Histone Code Modifications

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider