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August 2, 2026Human Brain MappingOpen Access

Methodological Choices Strongly Modulate the Sensitivity and Specificity of Lesion‐Symptom Mapping Analyses

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Authors

MMMargaret Jane MooreCRChris RordenGRGail Robinson

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Overview

Simulation analyses show how different methods affect accuracy in stroke survivors, suggesting optimal strategies.

Key Points

  • This research aims to clarify how different methodological choices influence the sensitivity and specificity of lesion-symptom mapping analyses.
  • Large-scale simulation using clinical imaging data from 959 stroke survivors.
  • Conducted 384,780 lesion-symptom mapping analyses varying sample inclusion criteria, analysis parameters, and analysis types.
  • Compared accuracy measures like percent coverage, Dice similarity coefficient, and false positives across designs.
  • Analysis accuracy varied widely based on the design used.
  • Maximizing lesion coverage with large diverse samples improved performance in all accuracy measures.
  • Multivariate approaches had higher accuracy for Dice coefficients, while univariate analyses had better target hit rates.

Cite This Study

Moore et al. (2026) studied this question.

synapsesocial.com/papers/6a6eea5d1b0468a7eeab29ddhttps://doi.org/10.1002/hbm.70619
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