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August 2, 2026International Heart JournalOpen Access

Empagliflozin Attenuates Ferroptosis in Acute Myocardial Infarction via the AMPK/NRF2/SLC7A11 Signaling Pathway

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Authors

XTXiangrui TangZXZhao XiaoxiaCLChunjun Liu

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Overview

Randomized trial investigates empagliflozin's impact on ferroptosis in myocardial infarction, suggesting a protective mechanism.

Key Points

  • This study examines the role of empagliflozin in suppressing ferroptosis during acute myocardial infarction.
  • Investigated the effects of empagliflozin on ferroptosis biomarkers in myocardial infarction models.
  • Analyzed the AMPK/NRF2/SLC7A11 signaling pathway related to myocardial injury.
  • Empagliflozin significantly reduced markers of ferroptosis in myocardial infarction.
  • Activation of AMPK and NRF2 was evident, supporting cell survival pathways.

Cite This Study

Tang et al. (2026) studied this question.

synapsesocial.com/papers/6a6eea811b0468a7eeab2d0fhttps://doi.org/10.1536/ihj.25-386
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