C-Myc Inhibition Using 10058-F4 Suppressed Ischemia Reperfusion Induced Cardiac Microvascular Endothelial Cell Pyroptosis through the Sam68/NF-κB Pathway

Over the past few decades, most cardiac reperfusion research has focused on the pathogenesis of myocardial ischemia reperfusion injury (MIRI), while little attention has been paid to microvascular ischemia reperfusion (I/R) injury, and few strategies have been available to reverse this pathological process. c-Myc, a proto-oncogene, is related to cardiomyocyte apoptosis and inflammation. It has been reported that Sam68 is involved in inflammatory disorders. However, whether c-Myc and Sam68 can modulate pyroptosis in cardiac microvascular endothelial cells (CMECs) remains unknown.