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Investigate the effects of diosgenin on satellite cell dynamics and muscle function in age-related sarcopenia.

August 2, 2026Aging CellOpen Access

Diosgenin Alleviates Age‐Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1 / PGC ‐1α Signaling Pathway

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Randomized trial demonstrates diosgenin enhances muscle function in aged mice, suggesting its therapeutic promise for sarcopenia.

Investigate the effects of diosgenin on satellite cell dynamics and muscle function in age-related sarcopenia.
Utilized naturally aged C57BL/6J mice and D-galactose-induced senescent C2C12 cell model
Evaluated forelimb grip strength, muscle index, and fiber area
Analyzed expression of markers related to myogenesis and signaling pathways
Diosgenin treatment improved forelimb grip strength and endurance in aged mice
Increased satellite cell proliferation and expression of myogenic markers
Inhibition of SIRT1 significantly reduced the effects of diosgenin treatment

Zeng et al. (2026) studied this question.

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