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This research evaluates trends in terminated clinical trials and the reasons behind these terminations over five years.

Terminated clinical trials: A 5-year global evaluation of trends and underlying causes

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This research evaluates trends in terminated clinical trials and the reasons behind these terminations over five years.
Analyzed data from ClinicalTrials.gov on trials terminated between 2018 and 2022.
Classified trials by year of termination, phase, and therapeutic area after manual scrutiny.
Total of 11,035 terminated trials were examined to determine reasons for termination.
25.4% of terminated trials were due to safety concerns.
31.91% of terminations occurred in phase 2 trials.
Hematology had the highest number of terminations at 13.7%, followed by oncology at 9.0%.

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Randomized trial identifies rising trends and reasons for termination in clinical trials, suggesting improved strategies.

Manoharan et al. (2026) studied this question.

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