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This study aims to explore the synergistic effects of antioxidant and epigenetic interventions on osteoarthritis-related chondrocyte senescence.

August 2, 2026Bioactive MaterialsOpen Access

Dual-modal antioxidant and epigenetic synergy attenuates the self-perpetuating senescence cycle in osteoarthritis

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Randomized trial demonstrates improved cartilage health in osteoarthritis models using synergistic antioxidant and epigenetic treatment.

This study aims to explore the synergistic effects of antioxidant and epigenetic interventions on osteoarthritis-related chondrocyte senescence.
Fabricated cartilage-targeted HPcLW nanoparticles co-loaded with lycopene and WTAP siRNA via electrostatic self-assembly.
Administered HPcLW nanoparticles intra-articularly in aged and DMM-induced osteoarthritis mouse models to evaluate effects on cartilage degeneration.
Measured joint fluorescence retention, COL2 expression, and MMP13 levels post-treatment.
Intra-articular HPcLW improved cartilage integrity and restored COL2 expression.
Significant reduction in MMP13 levels was noted with HPcLW treatment.
The WTAP siRNA effectively downregulated PAI-1 expression, demonstrating the disruption of the WTAP/PAI-1 axis.

An et al. (2026) studied this question.

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