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This research aims to optimize ultrasound-assisted extraction conditions for maximizing the beneficial compounds in Thymbra spicata.

Optimization of Ultrasound‐Assisted Extraction of Thymbra Spicata L. Using Response Surface Methodology: Polyphenol Profile and Antibacterial Activity

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Randomized trial optimizes antioxidant properties and antibacterial activity in Thymbra spicata, indicating effective extraction methods.

This research aims to optimize ultrasound-assisted extraction conditions for maximizing the beneficial compounds in Thymbra spicata.
Optimized extraction conditions using response surface methodology (RSM)
Used 31.071% methanol, 63.467°C, and a 36.14 mL/g solvent-to-solid ratio
Measured total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity (DPPH)
Achieved TPC of 145.77±2.26 mg GAE/g, TFC of 16.19±0.20 mg QE/g, and DPPH of 97.794±1.78 mg AAE/g
Identified key polyphenols including rosmarinic acid and luteolin-7-O-glucuronide
Detected antibacterial activity with MIC of 5 mg/mL and MBC of 10 mg/mL against Salmonella Typhimurium

Şirin et al. (2026) studied this question.

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