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August 2, 2026NutraceuticalsOpen Access

Neuroinflammation and Oxidative Stress in Neuropathic Pain: Mechanistic Targets for Nutraceutical-Based Interventions

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This review aims to summarize the mechanistic roles of neuroinflammation and oxidative stress in neuropathic pain and evaluate nutraceutical-based interventions.
Discussed the roles of neuroinflammation and oxidative stress in neuropathic pain mechanisms.
Examined evidence supporting various nutraceuticals like polyphenols, vitamins, and fatty acids for pain management.
Assessed preclinical studies on the effectiveness of dietary bioactive compounds in reducing pain-related behaviors.
Nutraceuticals can modify inflammatory signaling and promote mitochondrial function in neuropathic pain.
Certain compounds, such as alpha-lipoic acid and omega-3 fatty acids, show potential clinical promise, but evidence is still limited.
Preclinical findings indicate effectiveness in reducing nociceptive signaling and enhancing antioxidant defenses.

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Review summarizes mechanisms of neuroinflammation and oxidative stress in neuropathic pain, suggesting nutraceutical strategies for relief.

Martins et al. (2026) studied this question.

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Review summarizes mechanisms of neuroinflammation and oxidative stress in neuropathic pain, suggesting nutraceutical strategies for relief.