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August 2, 2026Annals of MedicineOpen Access

Granulomatous inflammation in histopathological samples: examining the aetiological spectrum, diagnostic challenges, and future perspectives

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Authors

PHPilar Hernández-JiménezMFMónica Sánchez de la FuenteJPJorge Macedo Pascual

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Overview

Retrospective analysis identifies aetiologies of granulomas in histopathological samples, suggesting improved diagnostic strategies.

Key Points

  • The study aims to categorize the primary diagnoses of granulomatous inflammation in histopathological samples and evaluate diagnostic challenges.
  • Retrospective analysis of 626 patients with granulomas over an 11-year period.
  • Assessment of demographic characteristics, histopathological patterns, and diagnostic tests performed.
  • Evaluation of primary causes of granulomas based on organ affected and patient demographics.
  • 56% of granulomas were non-necrotising and 24% were necrotising.
  • Infectious diseases were the leading cause of granulomas (22%; 138 cases), predominantly mycobacterial infections.
  • A structured diagnostic algorithm is proposed to enhance patient management and evaluation.

Cite This Study

Hernández-Jiménez et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeb201b0468a7eeab3f6ahttps://doi.org/10.1080/07853890.2026.2698144
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