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August 2, 2026Journal of Computational Biophysics and Chemistry

Leveraging Network Pharmacology, Molecular Docking to Discover Novel Multitarget Antidepressants

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Authors

DJDhananjay JoshiUAUrmila AswarBharati Vidyapeeth Deemed UniversityAGAnkit GaneshpurkarB. J. Medical College & Sassoon Hospital

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Implication

Randomized trial investigates multitarget antidepressants in addressing treatment-resistant depression, suggesting new therapeutic avenues.

Key Points

  • This review aims to identify novel multitarget antidepressants using in silico tools and evaluating their mechanisms of action.
  • Utilized network pharmacology and molecular docking to analyze antidepressant candidates.
  • Explored phytoconstituents from natural sources with potential antidepressant effects.
  • Focused on elucidating complex neurobiological processes involved in major depressive disorder.
  • Identified key pathways such as PI3K/Akt and MAPK relevant to antidepressant effects.
  • Confirmed that phytoconstituents show promising potential in modulating neurotransmitter imbalances.
  • Proposed new therapeutic strategies using ethnobotanicals for effective treatment options.

Cite This Study

Joshi et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeb3b1b0468a7eeab433fhttps://doi.org/10.1142/s2737416526300026
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