Clinical observation of opioid-sparing anesthesia combined with QLB in patients undergoing gynecological laparoscopic surgery: A randomized controlled trial

Background: Laparoscopic surgery has become the mainstream approach for gynecological procedures. However, postoperative pain, particularly visceral pain, remains a major obstacle to achieving enhanced recovery after surgery. Therefore, this study aimed to observe the clinical effects of opioid-sparing anesthesia combined with a quadratus lumborum block (QLB) in patients undergoing gynecological laparoscopic surgery to provide a reference for clinical practice. Methods: A total of 80 female patients (aged 18 to 65 years, body mass index 18 to 28 kg/m 2 , American Society of Anesthesiologists I–II) scheduled for elective gynecological laparoscopic surgery under general anesthesia were enrolled and randomly assigned to 2 groups (n = 40 each): the control group (Group C) and the treatment group (Group T). All patients received general anesthesia. In Group T, a bilateral QLB was additionally performed under ultrasound guidance after the induction of general anesthesia. The following parameters were recorded for both groups: general demographic data and perioperative parameters; total intraoperative remifentanil consumption; postoperative analgesic pump consumption at 0 to 24 hours and 24 to 48 hours; the number of effective presses and total presses of the analgesic pump during 0 to 24 hours and 24 to 48 hours postoperatively; numerical rating scale (NRS) scores at rest and during movement at 2 hours, 6 hours, 12 hours, 24 hours, and 48 hours postoperatively; the rescue analgesia rate within 48 hours postoperatively; and the incidence of adverse reactions (hypotension, respiratory depression, postoperative nausea and vomiting [PONV], somnolence). Results: Compared with Group C, patients in Group T had significantly reduced the following parameters: total intraoperative remifentanil consumption ( P < .05); analgesic pump consumption at 0 to 24 hours and 24 to 48 hours postoperatively ( P < .05); the number of effective presses and total presses of the analgesic pump during 0 to 24 hours and 24 to 48 hours postoperatively ( P < .05); resting NRS scores at 12 hours, 24 hours, and 48 hours postoperatively ( P < .05); and movement NRS scores at 6 hours, 12 hours, 24 hours, and 48 hours postoperatively ( P < .05). Furthermore, the rescue analgesia rate within 48 hours postoperatively was significantly lower in Group T compared to Group C ( P < .05). Regarding adverse reactions, the incidence of PONV in Group T was considerably lower than that in Group C ( P < .05). Conclusion: For gynecological patients undergoing laparoscopic surgery, the application of opioid-sparing anesthesia combined with a QLB provides effective analgesia, reduces intraoperative opioid consumption, prolongs the duration of postoperative analgesia, lowers the incidence of PONV, and promotes enhanced postoperative recovery.