Key result
Elevated plasma levels of MCP-1 measured 15 days after PTCA independently predicted restenosis at 6-month follow-up (beta=0.688, P<0.0001).
Population
50 patients who underwent percutaneous transluminal coronary angioplasty and had repeated angiograms at…
Design
Cohort
Follow-up
6 months
Authors
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May support post-PTCA MCP-1 monitoring for restenosis risk; hypothesis-generating for inflammation-targeted interventions.
Cohort (n=50)
Effect estimate: beta 0.688
p-value: p=<0.0001
Elevated plasma levels of MCP-1 after PTCA are independently associated with the development of angiographic restenosis at 6 months, suggesting a pathogenic role for inflammation and monocyte activation.
Cipollone et al. (2001) conducted a cohort in Restenosis after coronary angioplasty (n=50). Elevated plasma levels of MCP-1 vs. Lower plasma levels of MCP-1 was evaluated on Restenosis (beta 0.688, p=<0.0001). Elevated plasma levels of MCP-1 measured 15 days after PTCA independently predicted restenosis at 6-month follow-up (beta=0.688, P<0.0001).
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