Key result
Carotid endarterectomy is associated with an acute and prolonged increase in systemic oxidative stress that significantly correlates with the percentage of vessel renarrowing at 12 months.
Why the study?
Does elective endarterectomy induce systemic oxidative stress that correlates with late vascular remodeling in patients with internal carotid stenosis?
Population
45 patients undergoing elective endarterectomy for internal carotid stenosis
Design
Cohort
Follow-up
12 months
Authors
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Does not support changing CEA practice; hypothesis-generating for trials targeting oxidative stress to limit restenosis.
Cohort (n=45)
Does elective endarterectomy induce systemic oxidative stress that correlates with late vascular remodeling in patients with internal carotid stenosis?
Carotid endarterectomy induces an acute and prolonged increase in systemic oxidative stress that correlates with late luminal renarrowing at 12 months.
Mezzetti et al. (1999) conducted a cohort in Internal carotid stenosis (n=45). Elective endarterectomy vs. Baseline was evaluated on Systemic oxidative stress markers and percentage of vessel renarrowing at 12 months. Carotid endarterectomy is associated with an acute and prolonged increase in systemic oxidative stress that significantly correlates with the percentage of vessel renarrowing at 12 months.
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