Key result
Low responsiveness to clopidogrel and stage 3 to 5 CKD were independent predictors of the 1-year composite of myocardial infarction, ischemic stroke, and death in patients undergoing PCI.
Why the study?
Does low responsiveness to clopidogrel increase the risk of adverse cardiovascular events in CKD patients undergoing PCI?
Population
1567 patients with symptomatic coronary artery disease undergoing percutaneous coronary intervention…
Comparison
Low responsiveness to clopidogrel. vs Normal responsiveness to clopidogrel and/or…
Design
Cohort
Follow-up
1 year
Authors
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May indicate higher post-PCI risk with clopidogrel hyporesponsiveness in CKD; leaves open whether testing improves outcomes in trials.
Cohort (n=1,567)
Does low responsiveness to clopidogrel increase the risk of adverse cardiovascular events in CKD patients undergoing PCI?
Low responsiveness to clopidogrel is an independent risk factor for adverse cardiovascular outcomes in patients with stage 3 to 5 CKD undergoing PCI.
Htun et al. (2011) conducted a cohort in symptomatic coronary artery disease undergoing PCI (n=1,567). Low responsiveness to clopidogrel vs. Normal responsiveness to clopidogrel was evaluated on composite of myocardial infarction, ischemic stroke, and death within 1 year. Low responsiveness to clopidogrel and stage 3 to 5 CKD were independent predictors of the 1-year composite of myocardial infarction, ischemic stroke, and death in patients undergoing PCI.
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