Key result
Poor weight loss responders 5 years after bariatric surgery maintained metabolic benefits, though hypercholesterolaemia remission was lower compared to good responders (P=0.005).
Why the study?
To ascertain the 5-year metabolic effects of bariatric surgery in poor weight loss responders and establish associated factors.
Does bariatric surgery provide sustained metabolic benefits in patients with poor mid-term weight loss response?
Cohort (n=212)
Does bariatric surgery provide sustained metabolic benefits in patients with poor mid-term weight loss response?
p-value: p=0.005
Bariatric surgery provides sustained metabolic benefits at 5 years even in patients who experience suboptimal weight loss.
Metabolic benefits may persist despite poor weight loss after bariatric surgery; leaves open relevance of lower hypercholesterolaemia remission.
To ascertain the 5-year metabolic effects of bariatric surgery in poor weight loss (WL) responders and establish associated factors. Methods: Retrospective analysis of a non-randomised prospective cohort of bariatric surgery patients completing a 5-year follow-up. Mid-term poor WL was considered when 5-year excess weight loss was <50%. Results: Forty-three (20.3%) of the 212 included patients were mid-term poor WL responders. They showed an improvement in all metabolic markers at 2 years, except for total cholesterol. This improvement with respect to baseline was maintained at 5 years for plasma glucose, HbA1c, HOMA, HDL and diastolic blood pressure; however, LDL cholesterol, triglycerides and systolic blood pressure were similar to presurgical values. Comorbidity remission rates were comparable to those obtained in the good WL group except for hypercholesterolaemia (45.8% vs. poor WL, p = 0.005). On multivariate analysis, lower baseline HDL cholesterol levels, advanced age and lower preoperative weight loss were independently associated with poor mid-term WL. Conclusions: Although that 1 in 5 patients presented suboptimal WL 5 years after bariatric surgery, other important metabolic benefits were maintained.
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Benaiges et al. (2020) conducted a cohort in Obesity (post-bariatric surgery) (n=212). Poor mid-term weight loss (<50% excess weight loss) vs. Good weight loss was evaluated on Hypercholesterolaemia remission (p=0.005). Poor weight loss responders 5 years after bariatric surgery maintained metabolic benefits, though hypercholesterolaemia remission was lower compared to good responders (P=0.005).
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