Key result
A fully aliphatic, ether-free physically cross-linked polyurethane urea (HFL18-PU) demonstrated in vivo biostability, biocompatibility, and high flex-life (721 +/- 30 million cycles).
The newly developed HFL18-PU material shows promising mechanical properties and biocompatibility for potential use in polymer heart valves.
Supports HFL18-PU evaluation for polymer heart valves; leaves open human translation from animal data.
Development of new generation high flex life polyurethane urea (HFL18-PU) with appropriate elastic modulus, biocompatibility, blood compatibility, resistant to calcification, and biodurability for the long-term use as cardiac device is still a challenge. This study reports the development of a fully aliphatic, ether-free physically cross-linked and low elastic modulus (6.841 +/- 0.27 MPa) polyurethane urea having in vivo biostability, in vivo biocompatibility and high flex-life (721 +/- 30 million cycles) that can satisfy the requirements for the fabrication of tri-leaflet heart valve.
No takes yet. Share an insight, caveat, or question.
Thomas et al. (2008) studied Polymer heart valve development. High flex life polyurethane urea (HFL18-PU) was evaluated on In vivo biostability, in vivo biocompatibility and high flex-life. A fully aliphatic, ether-free physically cross-linked polyurethane urea (HFL18-PU) demonstrated in vivo biostability, biocompatibility, and high flex-life (721 +/- 30 million cycles).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: