Key result
Expression of the calcium-permeable cation channel CD20 in Balb/c 3T3 cells accelerated G1 progression, allowing 30% of quiescent cells to initiate DNA synthesis in response to IGF-I without priming.
Population
Balb/c 3T3 cells
Comparison
Transfection with cDNA encoding the Ca-permeable… vs Control cells
Design
Preclinical
Authors
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Hypothesis-generating for CD20 in growth factor responses; leaves open any cardiovascular relevance and should not change practice.
Expression of the CD20 calcium channel in Balb/c 3T3 cells accelerates G1 phase progression in a calcium-dependent manner.
Kanzaki et al. (1995) studied this question. Expression of CD20 vs. Control cells was evaluated on DNA synthesis in response to IGF-I without priming. Expression of the calcium-permeable cation channel CD20 in Balb/c 3T3 cells accelerated G1 progression, allowing 30% of quiescent cells to initiate DNA synthesis in response to IGF-I without priming.
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