Calcium-induced changes in thin filament structure regulate cross-bridge attachment and force development, driving the functional differences between skeletal and cardiac muscle.
Describes the molecular mechanisms of tropomyosin and troponin in regulating skeletal and cardiac muscle contraction.
Absolute Event Rate: 0% vs 0%
Changes in thin filament structure induced by Ca(2+) binding to troponin and subsequent strong cross-bridge binding regulate additional strong cross-bridge attachment, force development, and dependence of force on sarcomere length in skeletal and cardiac muscle. Variations in activation properties account for functional differences between these muscle types.
Gordon et al. (Sun,) reported a other. Calcium-induced changes in thin filament structure regulate cross-bridge attachment and force development, driving the functional differences between skeletal and cardiac muscle.