The binding of aminoacyl transfer RNA to ribosomes either in the presence (specific binding) or in the absence (nonspecific binding) of messenger RNA was inhibited by LiCl.This effect was partially reversible by NH,+ or K+.The ribosomes were completely dissociated into 50 S and 30 S subunits in the presence of 0.2 M LiCI.When LiCl was removed, the subunits associated again.The activity of ribosomes to synthesize polyphenylalanine in the presence of polyuridylic acid was recovered upon removal of LiCl.This reversible effect of LiCl was antagonized by the presence of a low concentration of NHa+.
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Suzuka et al. (1968) studied this question.
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